WebLike TGF-β, CTGF expression is increased in IPF patients. 104 Overexpression of CTGF can promote pulmonary fibrosis in animal models, 105 and blockade of CTGF signaling … WebThe TGF-beta receptor can regulate Smad and nonSmad signaling pathways, which then ultimately dictate TGF-beta's biological effects. We postulated that control of the level of TGFBR2 is a mechanism for regulating the specificity of TGF-beta signaling pathway activation and TGF-beta's biological effects.
Role of transforming growth factor-β in the progression of heart …
The primary cultures of orbital fibroblasts were established from surgical specimens of 4 patients with GO (G1-G4) during decompression surgery (one men and three women; mean age: 37.2 years) and from apparently normal orbital tissues in four age- and sex-matched patients (N1-N4), who received surgery for … See more The recombinant human TGF-β1 (#P01137) and TGF-β2 (#P61812) were purchased from R&D Systems, Inc. (Minneapolis, MN, USA), and the recombinant human CTGF protein (#PHG0286) was … See more The intracellular contents of human transforming growth factor-beta 1 (TGF-β1; catalog #DB100B) was quantified in cell culture supernatant by an enzyme-linked … See more About 1 × 107 cells were trypsinized, pelleted, washed with PBS, and then resuspended in the lysis buffer containing 50 mM Hepes (pH 7.4), 4 mM EDTA, 2 mM EGTA, 1 mM Na3VO2, 1 mM NaF, 1% Triton X-100, and … See more The small hairpin RNA (shRNA) plasmids for the CTGF gene (shCTGF) and luciferase control gene (shLuc) were obtained from the RNAi Core Facility at Academia Sinica, Taipei, Taiwan. The shLuc and shCTGF … See more WebMar 9, 2024 · Advanced glycation end-products induce tubular CTGF via TGF-beta-independent Smad3 signaling. In repetitive strain injury, substance P immunoexpression increased in week 12 peritendon as did CTGF-immunopositive fibroblasts. CTGF expression in epithelium was up-regulated early and urinary CTGF was markedly elevated from … fix bcd on different drive
TGF-β Signaling - PubMed
WebDec 2, 2008 · Alterations in components of the TGF-beta superfamily signaling pathways in human cancer. Cytokine Growth Factor Rev 2006; 17 :41–58. CAS PubMed Google Scholar WebObjectives There is increasing evidence that the endocannabinoid system may be involved in pathological fibrosis, and that its modulation might limit fibrotic responses. The aim of this study was to examine the capacity of a synthetic cannabinoid receptor agonist to modify skin fibrosis in the bleomycin mouse model of scleroderma. Methods Skin fibrosis was … WebTGF beta signaling is well known to contribute to processes involving the ocular anterior segment and IOP 113 as well as the glaucoma-related ... Intuitively, these effects should … fix bean pot lid