Web14 Mar 2024 · IDEAYA owns all commercial rights to IDE397 and its MAT2A program. IDEAYA is also clinically evaluating IDE161, a potential first-in-class PARG inhibitor, in a Phase 1/2 clinical trial for patients having tumors with HRD, including in BRCA1/2-mutant, ER+ / Her2- breast cancer, which represents approximately 10% to 14% of breast cancer. Web11 Mar 2024 · IDEAYA is an oncology-focused precision medicine company committed to the discovery and development of targeted therapeutics for patient populations selected …
IDEAYA Biosciences, Inc. Reports First Quarter 2024 Financial …
Web31 Jan 2024 · We believe PARG inhibitors could be substantially impactful for BRCA1 and BRCA2 patients non-responsive to PARP inhibitors. We are excited to advance IDE161 as a first-in-class development candidate toward the clinic," said Yujiro Hata , President and Chief Executive Officer of IDEAYA. Web1 Mar 2024 · The first PARG inhibitors gallotannin and GPI-16552 showed low activity in vitro and off-target effects in cells (Falsig et al. 2004; Erdèlyi et al. 2005). ADP-HPD and rhodanine-based PARG inhibitors (RBPIs) are potent and specific inhibitors, but lack cell permeability (Slama et al. 1995; Finch et al. 2012). psers 2022-23 rates
Pipeline – IDEAYA Biosciences
Web10 Mar 2024 · This patent search tool allows you not only to search the PCT database of about 2 million International Applications but also the worldwide patent collections. This search facility features: flexible search syntax; automatic word stemming and relevance ranking; as well as graphical results. Web4 Apr 2024 · IDE161 is an orally bioavailable small molecule inhibitor of PARG. Biochemical and cellular assays demonstrate that IDE161 is a potent inhibitor of PAR chain hydrolysis and has anti-proliferative activity in breast and ovarian HRD cancer cell lines with both inherent and acquired PARPi resistance. Web14 Mar 2024 · 14th March 2024 by Selina McKee Cancer Research UK is partnering with US biotech Ideaya Biosciences to develop small molecule inhibitors of Poly (ADP-ribose) … psers act 9